In a small bowl, whisk together brown sugar, Worcestershire sauce, liquid smoke, black pepper, garlic powder, mustard, and salt. Rub all over brisket.
Place in a gallon-sized zipper-top plastic bag or in a dish with a cover. Refrigerate at least 30 minutes or overnight.
Transfer the brisket to a slow cooker. Cover and cook on low until meat is fork-tender, about 8 to 10 hours.
Preheat broiler on HIGH and cover a rimmed baking sheet with foil. Remove brisket from slow cooker and transfer to prepared baking sheet. Brush brisket with barbecue sauce on all sides. Broil until sauce is sticky and bubbly, about 1 to 2 minutes.
Remove brisket to a cutting board and tent with foil for 10 minutes. Slice brisket thinly across the grain and serve with additional barbecue sauce on the side.
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Notes
Brisket: Look for flat cut brisket which is rectangular in shape and has a fat cap. If your brisket doesn’t fit in the Dutch oven for browning, cut it in pieces and sear in batches.
Barbecue sauce: Save time with your favorite store-bought sauce, or try my Sweet Baby Ray’s copycat Barbecue Sauce recipe ready in just 20 minutes.
Yield: This Slow Cooker Brisket recipe makes enough for 8 generous entree-sized servings.
Storage: Store leftovers covered in the refrigerator for up to 4 days.